The 9th International Symposium on Autophagy

Nov 3~7, 2019 Taipei, Taiwan

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EVENT SCHEDULE

DAY 1 DAY 2 DAY 3 DAY 4 DAY 5

DAY 1: NOVEMBER 3 (Sun), 2019

13:30 - 15:00 Registration
15:00 - 15:05 Opening Remarks
Todd Lowary
Guang-Chao Chen
15:05 - 15:30
Special Talk
Dr. Yoshinori Ohsumi, Tokyo Institute of Technology, Japan

Looking back on 30 years of autophagy research - What have we learned from yeast?

* Session 1: Mechanism of autophagy 1
Chair: Sharon Tooze, Chao-Wen Wang
15:30 - 16:20
Keynote speech
Noboru Mizushima, The University of Tokyo, Japan

Physiological roles of autophagy and related pathways in vertebrates

16:20 - 16:40 Coffee break
16:40 - 17:05 Sharon A. Tooze, The Francis Crick Institute, UK

Initiation of autophagosome formation

17:05 - 17:30 Zvulun Elazar, Weizmann Institute of Science, Israel

A novel autophagy-related mouse model for studying neurodegeneration

17:30 - 17:45 Short talk 1 - Liang Ge,

ERGIC regulates the dual function of autophagy

Performance - Hualien Tai-Ping Primary School
Group photo
18:30 - Welcome party

DAY 2: NOVEMBER 4 (Mon), 2019

* Session 2: Mechanism of autophagy 2
Chair: Ming-Daw Tsai, Nobuo N. Noda
09:00 - 09:25 Carsten Sachse, Research Centre Jülich, Germany

Structural mechanism of p62/SQSTM1 assembly and autophagy clearance

09:25 - 09:50 Nobuo N. Noda, Institute of Microbial Chemistry (BIKAKEN) Tokyo, Japan

Mechanisms of autophagosomal membrane expansion and shaping

09:50 - 10:05 Short talk 2 - Adam Yokom,

Architecture and Assembly of Mammalian ULK1 Complex

10:05 - 10:20 Short talk 3 - Roland Knorr,

Intracellular capillary origami: how membranes sequester phase-separated droplets during autophagy

10:20 - 10:50 Coffee break
* Session 3: Cancer and disease 1
Chair: Ruey-Hwa Chen, Han-Ming Shen
10:50 - 11:15 Jun-Lin Guan, University of Cincinnati College of Medicine Cincinnati

Analysis of autophagy genes in breast cancer relapse and TSC-deficient neural stem cells

11:15 - 11:40 Myung-Shik Lee, Yonsei University, Korea

Effect of autophagy enhancement on systemic metabolism

11:40 - 11:55 Short talk 4 - Aditya Murthy,

Autophagy regulates necroptosis via turnover of RHIM-domain proteins

11:55 - 12:10 Short talk 5 - Hagai Abeliovich,

Mechanisms of selective protein recruitment during stationary phase mitophagy

12:10 - 12:25 Flash talks I – P7, P13, P23, P31, P57, P67, P115, P, 117
12:25 - 13:30 Lunch
13:30 - 15:00 Poster session I
* Session 4: Mechanism of autophagy 3
Chair: Yi-Ching Wang, Alan Yuen-Luen Lee
15:00 - 15:25 Kevin Ryan, Beatson Institute for Cancer Research, UK

Nutrient supply, autophagy and cancer

15:25 - 15:50 Ruey-Hwa Chen, Academia Sinica, Taiwan

VPS34 heterotypic ubiquitination regulates proteostasis

15:50 - 16:05 Short talk 6 - Shigeomi Shimizu,

New insights into the mechanism of Atg5-independent alternative autophagy using chemical biology approach

16:05 - 16:20 Short talk 7 - Wen-Ching Wang,

Cholesterol glucosylation by Helicobacter pylori regulates autophagy to escape macrophage clearance

16:20 - 16:50 Coffee break
* Session 5: Mechanism of autophagy 3
Chair: Wan-Wan Lin, Myung-Shik Lee
16:50 - 17:15 Nicholas Ktistakis, Brabraham Institute, UK

Dynamics of selective and non-selective autophagy: the early steps

17:15 - 17:40 Hong Zhang, Chinese Academy of Sciences, China

ER-localized SUSR2 controls trafficking of the PtdIns(4)P phosphatase SAC1 to modulate autophagy activity

17:40 - 17:55 Short talk 8 - Yaowen Wu,

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

17:55 - 18:10 Short talk 9 - Thomas Wollert,

The selectivity in autophagy is coordinated at the level of initiation

18:10 - 18:25 Short talk 10 - Xiaohong Zhuang,

Molecular mechanism of membrane trafficking in plant autophagy

DAY 3: NOVEMBER 5 (Tue), 2019

* Session 6: Selective autophagy
Chair: Wei Yuan Yang, Yi-Cherng Liou
09:00 - 09:25 Richard J. Youle, NINDS, National Institutes of Health, USA

Mechanisms of Mitophagy

09:25 - 09:50 Susan Ferro-Novick, University of California, San Diego, USA

A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation

09:50 - 10:15 Ivan Dikic, Goethe University Frankfurt, Germany

Endoplasmic reticulum remodeling via ER-phagy

10:15 - 10:30 Short talk 11 - Hitoshi Nakatogawa,

Atg8-mediated super-assembly of Atg40 locally remodels the ER during ER-phagy

10:30 - 10:50 Coffee break
* Session 7: Infection and immunity 1
Chair: Wen-Ching Wang, Jr-Wen Shui
10:50 - 11:15 Jing-Hsiung James Ou, University of Southern California, USA

Hepatitis B Virus and Autophagy

11:15 - 11:40 Yee-Shin Lin, National Cheng Kung University, Taiwan

Xenophagy and LC3-associated phagocytosis in group A streptococcal infection

11:40 - 11:55 Short talk 12 - Eun-Kyeong Jo,

Autophagy in GABAergic Host Defense

11:55 - Lunch
Excursion

DAY 4: NOVEMBER 6 (Wed), 2019

* Session 8: Mechanism of autophagy 4
Chair: Fang-Jen Lee, Wei-Pang Huang
09:00 - 09:25 Fulvio Reggiori, University of Groningen, Netherlands

Supplying lipids to forming autophagosomes

09:25 - 09:50 Li Yu, Tsinghua University, China

Autophagic lysosome reformation

09:50 - 10:15 Anne Simonsen, University of Oslo, Norway

Regulation of selective autophagy by lipid-binding proteins

10:15 - 10:30 Short talk 13 - Fang-Jen Lee,

The Arl3 and Arl1 GTPase cooperates with Cog8 to regulate selective autophagy via Atg9 trafficking

10:30 - 10:50 Coffee break
* Session 9: Cancer and disease 2
Chair: Hong Zhang, Po-Yuan Ke
10:50 - 11:15 Ana Maria Cuervo, Albert Einstein College of Medicine, USA

Chaperone-mediated autophagy and age-related diseases

11:15 - 11:40 Masaaki Komatsu, Juntendo University Graduate School of Medicine, Japan

Molecular mechanism of selective turnover of p62-liquid droplets

11:40 - 11:55 Short talk 14 - Radek Dobrowolski,

Starvation-Induced Endocytosis Is TFEB-Driven and Required to Coordinate MTORC1 Signaling and Autophagy

11:55 - 12:10 Short talk 15 - Takeshi Noda,

Erdj8 governs the size of autophagosomes during the formation process

12:10 - 12:25 Flash talks II – P4, P30, P48, P60, P68, P94
12:25 - 13:30 Lunch
13:30 - 15:00 Poster session II
* Session 10: Autophagy in neuron and development 1
Chair: Yi-Juang Chern, Yung-Feng Liao
15:00 - 15:25 David C. Rubinsztein, Cambridge Institute for Medical Research, UK

Autophagy and neurodegeneration

15:25 - 15:40 Short talk - Shu-Yi Huang,

Dihydroceramide desaturase regulates the switch between exosome secretion and autophagy for neuronal maintenance

15:40 - 15:55 Short talk 16 - Congcong He,

Autophagy regulates dopaminergic neurotransmission and reward behaviors

15:55 - 16:10 Short talk 17 - Thierry Galli,

VAMP7-dependent autophagic secretion allows for axonal growth in nutrient restriction conditions

16:10 - 16:40 Coffee break
* Session 11: Autophagy in neuron and development 2
Chair: Chih-Chiang Chan, Chi-Kuang Yao
16:40 - 17:05 Zhenyu Yue, Mount Sinai Medical Center, USA

Glial Autophagy and Neurodegenerative Disease

17:05 - 17:30 Xiaochen Wang, Chinese Academy of Sciences, China

Degradation of autophagic cargo in lysosomes

17:30 - 17:45 Short talk 18 - Renaud Legouis,

Deciphering the functions of LGG-1/GABARAP precursor and non-lipidated forms in autophagy and development in C. elegans

17:45 - 18:00 Short talk 19 - Shuo-Chien Ling,

Deregulation of mediated autophagy by C9ORF72 are linked with ALS/FTD and corticobasal degeneration

18:00 - 18:15 Short talk 20 - Yasuyoshi Sakai,

Diverse modes of microautophagy: lessons from yeast studies

18:15 - Banquet

DAY 5: NOVEMBER 7 (Thu), 2019

* Session 12: Infection and immunity 2
Chair: Yee-Shin Lin, Chih-Peng Chang
09:00 - 09:25 Vojo Deretic, University of New Mexico Health Sciences Center, USA

Unanticipated mechanism of action of mammalian Atg8s

09:25 - 09:50 Subash Sad, University of Ottawa, Canada

Impact of FoxO3a signaling in metabolism and inflammation

09:50 - 10:05 Short talk 21 - Yating Wang,

Select autophagy genes maintain quiescence of tissue-resident macrophages and susceptibility to infection

10:05 - 10:25 Coffee break
* Session 13: Mechanism of autophagy 5
Chair: Masaaki Komatsu, Wei-Chung Chiang
10:25 - 10:50 Tamotsu Yoshimori, Osaka University, Japan

Novel mechanistic insights into how cells promote lysophagy

10:50 - 11:15 Wei-Yuan Yang, Academia Sinica, Taiwan

tMPT in fast forwarding autophagosomal membrane elongation

11:15 - 11:40 Han-Ming Shen, National University of Singapore, Singapore

Novel regulatory mechanisms of mitophagy: post-translational modifications and beyond

11:40 - 12:05 Guang-Chao Chen, Academia Sinica, Taiwan

Analysis of protein tyrosine phosphatases in autophagy- lessons from fly

12:05 - 12:15 Poster award ceremony - Ruey-Hwa Chen
Closing remarks - Guang-Chao Chen
Departure