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• Extracellular vesicles
• Molecular bioimaging
• Pharmacology

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• Structure and function of membrane proteins and glycoproteins
• Drug discovery research

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• Bio-organic and synthetic organic chemistry

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My lab is fascinated by the mechanisms underlying the complicated yet organized cellular crosstalks in the nervous system.

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• Carbohydrate Chemistry
• Glycobiochemistry
• Glycobiology
• Enzymology

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• To understand the mechanisms by which DNA damage response is controlled to prevent genome instability.

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• Venom proteomics
• Multi-omics
• Venom protein structure and function
• Biomedical application of snake venom proteins and toxins.

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• Cancer
• Gene expression
• Signaling network
• Biomedical engineering
• Systems biology
• Quantitative cell biology

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• Carbohydrate synthesis
• Antibody modification
• Glyan and protein microarray

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• Drug discovery
• Glycoscience,
• Gut micribiota
• Metabolomics.

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• Molecular and Cellular Signaling

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• Natural Product Biosynthesis

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• Controlled-release of liposome for advanced drug delivery
• Biochemical applications of novel luminescence materials including upconversion nanoparticle and photosensitizers
• Protein / enzyme engineering

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Our research has focused on metabolism, including its biochemistry, evolution, and regulation.

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• Organic synthesis
• Chemical biology and drug discovery: We are interested in using organic chemistry as chemical tools to study and address in biology.

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• Bioconjugation reactions
• Biosynthetic enzymes
• Directed evolution
• Peptide natural products

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• Protein misfolding in neurodegenerative diseases
• Nanomedicine
• Molecular probe development

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My focus is to investigate and manipulate the innate immune systems using chemical biology, and to develop lead compounds and protein drugs against inflammatory disorders.

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Molecular mechanisms underlying cardiac regeneration and organ fibrosis

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• Mass Spectrometry based Protein Glycosylation Analysis
• Glycomics, and Glycobiology

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• Study of the mechanisms underlying immune cell development and effector functions, with an emphasis on post-translational modifications.
• Development of antibodies for disease therapy.

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• Natural medicine
• Cancer pharmacology
• Industrial enzyme biotechnology
• Metabolomics

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• Drug abuse
• Nociception
• Orexins
• cannabinoids
• Opioid receptors/GIRK channels
• CNS Drug development
• Synaptic plasticity
• Synaptic transmission

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• Kinetics, mechanisms, and inhibitors of enzymes
• Anti-cancer drug discovery targeting protein-protein interactions
• Cellulose / hemicellulose degrading enzymes for biofule production

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• Protein Chemistry
• Alzheimer's disease
• Prion
• Antimicrobial peptide

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• Organic synthesis
• Asymmetric catalysis
• Drug discovery

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• Carbohydrate Chemistry
• Glycoscience

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• Metallo-enzymes and bio-mimetics for catalytic conversions of hydrocarbons
• Physiological roles of iron-sulfur complexes in transcriptional factors from Prokaryotic systems

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• Pharmacology & Immunology

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• Genome engineering of human immune cells

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• Glycobiology

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• Carbohydrate chemistry
• Organic
• Carbohydrate biochemistry
• Carbohydrate-protein interactions studies

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• Natural products chemistry
• Drug discovery
• Structural and mechanistic enzymology
• Synthetic biology

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• Inflammation and cancer
• Induced pluripotent stem cells
• Vascular diseases
• Drug discovery and development.

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• Chemical biology on neurotransmission and ion channels

• Neurotechnology development (with special emphasis on optogenetics)

• Brain-body interactions

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• Innate immunity
• Cell death
• Inflammation
• Macrophage 
• Protein kinase
• Signal transduction

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• The Wei Chen Lab possesses multidisciplinary expertise in Nanomedicine, Biomedical Engineering, Drug Delivery, Chemistry, Materials Science, Nanotechnology, Immunology, and Biology. Our research interest spans the innovation of nanoparticles, two-dimensional materials, hydrogels, and RNA nanomedicine, as well as living materials like engineered microalgae, microbes, and cells. These materials find diverse applications in disease treatment, vaccine development, and translational medicine. Our innovations are aimed at enabling efficient therapeutic delivery to targeted areas, addressing a range of diseases such as cancer, atherosclerosis, inflammatory diseases, while also exploring applications in anti-aging and tissue regeneration.

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• Organic chemistry
• Natural product-inspired combinatorial chemistry
• Modulation of sugar-processing enzymes
• Drug discovery

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• Analytical and physical chemistry
• Biochemical and biotechnological applications of mass spectrometry
• Structure elucidation and unimolecular dissociation mechanisms of bio macromolecules

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• Protein misfolding and neurodegenerative diseases

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• Adaptive Immunity
• Omics and Precision Medicine
• Antigen Presenting Cells
• Vaccine Development

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• Protein engineering for biosensor development