TIGP
The Chemical Biology and Molecular Biophysics Program in
Drug Discovery and Biotechnology
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TIGP – CBMB

Faculty as Supervisor

The CBMB faculty on the list can take a student(s).
Chinese Name English Name Research Note
賴品光 Charles Lai Bionanotechnology, molecular bioimaging, extracellular vesicles (e.g. exosomes, microvesicles), gene therapy, cell-to-cell communication, pharmacokinetics.
馬徹 Che Alex Ma Structure and function of membrane proteins and glycoproteins; drug discovery research in drug-resistant bacterial and viral infections, universal vaccines and cancers.
王正中 Cheng-Chung Wang Carbohydrate Chemistry
謝佳龍 Chia-Lung Hsieh Molecular dynamics in live cells by advanced optical microscopy
黃至正 Chih-Cheng Huang Nanomagnetism and Bioelectronics, MagnetoBiology. Can take students from 114 academic year
姚季光 Chi-Kuang Yao My lab is fascinated by the mechanisms underlying the complicated yet organized cellular crosstalks in the nervous system.
游景晴 Ching-Ching Yu Carbohydrate Chemistry, Glycobiochemistry, Glycobiology, Enzymology. Can take students from 114 academic year
吳青錫 Ching-Shyi Wu To understand the mechanisms by which DNA damage response is controlled to prevent genome instability.
陳子福 Choo Hock Tan Venom proteomics; Multi-omics; Venom protein structure and function; Biomedical application of snake venom proteins and toxins. Can take students from 114 academic year
王群超 Chun-Chao Wang Cancer, gene expression, signaling network, biomedical engineering, systems biology, and quantitative cell biology. Can take students from 114 academic year
林俊成 Chun-Cheng Lin Carbohydrate synthesis, antibody modification, and glyan and protein microarray
林俊宏 Chun-Hung Lin Drug discovery, Glycoscience, Gut micribiota, Metabolomics
陳光超 Guang-Chao Chen Molecular and Cellular Signaling Autophagy
林曉青 Hsiao-Ching Lin Natural Product Biosynthesis
李賢明 Hsien-Ming Lee Controlled-release of liposome for advanced drug delivery; biochemical applications of novel luminescence materials including upconversion nanoparticle and photosensitizers; Protein / enzyme engineering.
嚴欣勇 Hsin-Yung (Jason) Yen Investigating the structural dynamics and mechanisms of membrane proteins using state-of-the-art mass spectrometry
涂熊林 Hsiung-Lin Tu Surface Physical and Materials Chemistry, Chemical and Systems Biology
冀宏源 Hung-Yuan Chi DNA damage and Repair
Genome stability and Cancer
Biochemistry
謝俊結 Jiun-Jie Shie Organic synthesis, chemical biology and drug discovery: We are interested in using organic chemistry as chemical tools to study and address in biology.
朱忠瀚 John Chu While natural products have and continue to inspire the design of new drugs, we see them more broadly as part of the chemical language of nature, whose function could help us better understand how living organisms communicate with each other and interact with the environment. My research group takes unconventional approaches towards natural product discovery and the study of their bio- and chemical syntheses.
黃人則 Joseph Jen-Tse Huang Protein misfolding in neurodegenerative diseases, Nanomedicine, Molecular probe development
翁瑞霞 Jui‐Hsia Weng My focus is to investigate and manipulate the innate immune systems using chemical biology, and to develop lead compounds and protein drugs against inflammatory disorders.
楊鎧鍵 Kai-Chien Yang Molecular mechanisms underlying cardiac regeneration and organ fibrosis
邱繼輝 Kay-Hooi Khoo Mass Spectrometry based Protein Glycosylation Analysis, Glycomics, and Glycobiology
林耿慧 Keng-Hui Lin Physical Cell Biology
吳昆峯 Kuen-Phon Wu Structural mechanism of protein ubiquitination involved in human diseases; structural biology and protein chemistry.
夏國強 Kuo-Chiang Hsia The spatial organization of the cellular cytoplasm has fascinated cell biologists since the advent of microscopy. My research is centered on unraveling the complexities underlying the organization and functionality of micron-sized microtubule arrays. Specifically, I investigate their roles in facilitating mitosis progression, ciliogenesis, and neuronal maturation. Additionally, I explore how nuclear transport factors influence the organization of microtubule-based structures, such as the spindle and anemone, through both canonical and non-canonical activities. Beyond fundamental cell biology, my research extends to understanding the molecular mechanisms underlying cancer drug resistance. Given the significance of tubulin as a target for anti-cancer drugs, we are focusing on elucidating the mechanisms responsible for drug resistance. This study aims to deepen our understanding of cancer drug resistance and potentially uncover new avenues for the development of more effective cancer treatments. In pursuit of these objectives, we reconstitute and image the self-organization of microtubule-based structures from the protein building blocks. In the lab, we apply an interdisciplinary approach, including biochemical, structural biology, biophysical and cell biology methods, to uncover cellular mechanisms. Through our endeavors, the ultimate goal is to unveil the mechanistic links connecting cytoskeletal organization with essential cell functions. Can take students from 114 academic year
林國儀 Kuo-I Lin
  1. Study of the mechanisms underlying immune cell development and effector functions, with an emphasis on post-translational modifications
  2. Development of antibodies for disease therapy
徐麗芬 Lie-Fen Shyur Natural medicine; Cancer pharmacology; Industrial enzyme biotechnology; Metabolomics
何孟樵 Meng-Chiao Joseph Ho CryoEM, protein crystallography, glycan binding protein for diagnosis, plant submergence responses, DNA repair machinery
梁博煌 Po-Huang Liang Kinetics, mechanisms, and inhibitors of enzymes; anti-cancer drug discovery targeting protein-protein interactions; cellulose/hemicellulose degrading enzymes for biofule production
陳佩燁 Rita P.-Y. Chen Protein Chemistry, Alzheimer's disease, prion, antimicrobial peptide
陳榮傑 Rong-Jie Chein Organic synthesis, asymmetric catalysis, drug discovery
陳瑞華 Ruey-Hwa Chen Protein folding and misfolding; mechanism and prevention of prion formation; therapy of Alzheimer's disease.
俞聖法 Sheng-Fa Steve Yu Metallo-enzymes and bio-mimetics for catalytic conversions of hydrocarbons; physiological roles of iron-sulfur complexes in transcriptional factors from Prokaryotic systems.
陳昇宏 Sheng-hong Chen Our lab is interested in revealing hidden biological rhythms and in deciphering their underlying regulatory principles. Rhythmic systems that we investigate include oscillators, toggle switches and trigger waves, especially those that govern cellular survival, death, and differentiation. We take a multifaced quantitative approach integrating concepts and methods in biology, mathematics, engineering and informatics. Our ultimate goal is to reveal general principles in biology for its design and control. Can take students from 115 academic year
徐尚德 Sheng-Te Danny Hsu Integrative structural biology focusing on the functional dynamics of biomedically important protein targets, including coronavirus spike proteins. Tools include cryo-EM, NMR, crystallography, SAXS, MS and molecular modeling to help glean insights into the structural basis of functional regulations.
凌嘉鴻 Steven Lin Genome engineering of human immune cells
林世昌 Su-Chang Lin To unravel the signaling mechanisms in immune responses and tumor development by the reconstitution of the signaling complexes and subsequent structural and functional studies.
安形高志 Takashi Angata Glycobiology
李宗璘 Tsung-Lin Li Natural products chemistry; drug discovery; structural and mechanistic enzymology; Synthetic biology.
魏子堂 Tzu-Tang Thomas Wei Inflammation and cancer; induced pluripotent stem cells; vascular diseases; drug discovery and development.
林宛蓁 Wan-Chen Lin We develop chemical, optogenetic, and other genetically-encoded tools to unlock the mystery of neurotransmission in the brain.
林琬琬 Wan-Wan Lin Innate immunity, Cell death, Inflammation, Macrophage, Protein kinase, Signal transduction.
陳緯 Wei Chen Nanomedicine, Biomedical Engineering, Drug Delivery, Chemistry, Materials Science, Nanotechnology, Immunology, and Biology Can take students from 114 academic year
鄭偉杰 Wei-Chieh Cheng Organic chemistry, natural product-inspired combinatorial chemistry, modulation of sugar-processing enzymes, drug discovery
章為皓 Wei-Hau Chang Using cryo-electron microscopy, single-molecular imaging, and bioorthogonal chemical methods to probe the dynamics and kinetics underlying the machinery of transcription, splicing, virus entry or other processes.
楊維元 Wei-Yuan Yang Autophagy, Organelle damage responses, Cell imaging, Optogenetics
劉懿璇 Yi-Shiuan Liu
  1. The effects of biomechanical forces on the differentiation of mesenchymal stem cells (MSCs)
  2. Cancer immunotherapy
Can take students from 115 academic year
陳玉如 Yu-Ju Chen Analytical and physical chemistry; biochemical and biotechnological applications of mass spectrometry; structure elucidation and unimolecular dissociation mechanisms of bio macromolecules
史有伶 Yu-Ling Shih Metabolic regulation of bacterial growth and division
Cell wall synthesis and cell shape
Host-pathogen interactions
李永凌 Yungling Leo Lee Adaptive Immunity, Omics and Precision Medicine, Antigen Presenting Cells, Vaccine Development. Can take students from 114 academic year
陳韻如 Yun-Ru Ruby Chen Protein misfolding and neurodegenerative diseases
那須雄介 Yusuke Nasu Can take students from 115 academic year Can take students from 115 academic year