Membrane Protein Research and NMR spectroscopy

Computational biology; bioinformatics; theoretical biophysics and chemistry; molecular model development; protein-protein interaction; (Non)-equilibrium dynamics, conformational changes and interactions of essential enzymes, RNA molecules, ribosome, ion channels and growth factors; peptide and protein design. (wet and dry)

G-protein structure and signal transduction in plant, reguation and specificity study of G-protein signal transduction using fluorescent probe modified RGS protines, structural and kenetic study of photosensory signal transduction in halobacteria

Structural and functional analyses of vaccinia viral proteins and protein-protein complexes; solid-state NMR characterization of steroidal conformation.

Physical Cell Biology

Using cryo-electron microscopy, single-molecular imaging, and bioorthogonal chemical methods to probe the dynamics and kinetics underlying the machinery of transcription, splicing, virus entry or other processes.

Structural biology, protein engineering, structure-based drug discovery

Investigating the structural dynamics and mechanisms of membrane proteins using state-of-the-art mass spectrometry.

Structural dynamics of tyrosine phosphatases; host-microbiome interaction

Structural mechanism of protein ubiquitination involved in human diseases; structural biology and protein chemistry.

CryoEM, protein crystallography, glycan binding protein for diagnosis, plant submergence responses, DNA repair machinery

• Metabolic regulation of bacterial growth and division
• Cell wall synthesis and cell shape
• Host-pathogen interactions

To unravel the signaling mechanisms in immune responses and tumor development by the reconstitution of the signaling complexes and subsequent structural and functional studies.

We focused on development and application of novel computational methods, including artificial intelligence approaches, for drug discovery and structural bioinformatics.

Integrative structural biology focusing on the functional dynamics of biomedically important protein targets, including coronavirus spike proteins. Tools include cryo-EM, NMR, crystallography, SAXS, MS and molecular modeling to help glean insights into the structural basis of functional regulations.

Surface Physical and Materials Chemistry, Chemical and Systems Biology.

Protein folding and misfolding; mechanism and prevention of prion formation; therapy of Alzheimer's disease.

• Autophagy
• Organelle damage responses
• Cell imaging
• Optogenetics

• DNA damage and Repair
• Genome stability and Cancer
• Biochemistry

Molecular dynamics in live cells by advanced optical microscopy