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Research:
Carbohydrate Chemistry
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Innate immunity, Cell death, Inflammation, Macrophage, Protein kinase, Signal transduction.
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My lab is fascinated by the mechanisms underlying the complicated yet organized cellular crosstalks in the nervous system.
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Molecular mechanisms underlying cardiac regeneration and organ fibrosis
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Structure and function of protein, carbohydrate and natural products
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To understand the mechanisms by which DNA damage response is controlled to prevent genome instability.
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Bio-organic and synthetic organic chemistry.
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Pharmacology & Immunology
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Structure and function of membrane proteins and glycoproteins; drug discovery research in drug-resistant bacterial and viral infections, universal vaccines and cancers.
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We develop chemical, optogenetic, and other genetically-encoded tools to unlock the mystery of neurotransmission in the brain.
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carbohydrate synthesis, antibody modification, and glyan and protein microarray
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The Liao Lab has been working on problems that integrate Synthetic Biology, Metabolic Engineering, Bioinformatics, and Systems Biology, primarily to address the climate change issue. In the past, the Lab has developed pathways for biosynthesis of various chemicals , and invented novel pathways for C1 metabolism, which included Non-Oxidative Glycolysis , methanol condensation cycle (MCC), malyl-CoA-glycerate (MCG) pathway, reverse glyoxylate pyruvate synthesis (rGPS) pathway. Recent focus has been on the use of design and evolution methodologies for constructing synthetic organisms that utilize C1 substrates (methane, methanol, formic acid, CO2) as the sole carbon source. Our working organisms include E. coli, cyanobacteria, and plants.
The Lab also integrates chemical, electrochemical, and biological methods for carbon fixation.
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Bionanotechnology, molecular bioimaging, extracellular vesicles (e.g. exosomes, microvesicles), gene therapy, cell-to-cell communication, pharmacokinetics.
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Mass Spectrometry based Protein Glycosylation Analysis, Glycomics, and Glycobiology
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Carbohydrate Chemistry and Glycoscience
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Lectin-pathogen interactions, Lectin-mediated fat metabolism
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While natural products have and continue to inspire the design of new drugs, we see them more broadly as part of the chemical language of nature, whose function could help us better understand how living organisms communicate with each other and interact with the environment.
My research group takes unconventional approaches towards natural product discovery and the study of their bio- and chemical syntheses.
Research:
Drug abuse, Nociception, Orexins, cannabinoids, Opioid receptors/GIRK channels, CNS Drug development, Synaptic plasticity, Synaptic transmission
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Organic chemistry, natural product-inspired combinatorial chemistry, modulation of sugar-processing enzymes, drug discovery
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Analytical and physical chemistry; biochemical and biotechnological applications of mass spectrometry;
structure elucidation and unimolecular dissociation mechanisms of bio macromolecules
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Organic synthesis, asymmetric catalysis, drug discovery
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Study of the mechanisms underlying immune cell development and effector functions, with an emphasis on post-translational modifications.
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Development of antibodies for disease therapy.
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My focus is to investigate and manipulate the innate immune systems using chemical biology, and to develop lead compounds and protein drugs against inflammatory disorders.
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Genome engineering of human immune cells
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Development of new synthetic methods and strategies; synthesis of natural products and biologically active compounds; drug design and synthesis; molecular genomic; bionano science & technology.
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Development of cell-based therapeutics for diabetes; Dissecting roles of cell reprogramming events in tumorigenesis.
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Natural products chemistry; drug discovery; structural and mechanistic enzymology; Synthetic biology.
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Metallo-enzymes and bio-mimetics for catalytic conversions of hydrocarbons; physiological roles of iron-sulfur complexes in transcriptional factors from Prokaryotic systems.
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Expanding genetic codes, protein chemistry, protein polyhetero-Ub/SUMO modifications, biocatalysis and protein drug discovery.
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Controlled-release of liposome for advanced drug delivery; biochemical applications of novel luminescence materials including
upconversion nanoparticle and photosensitizers; Protein / enzyme engineering.
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Drug discovery, Glycoscience, Gut micribiota, Metabolomics.
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Natural Product Biosynthesis
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Kinetics, mechanisms, and inhibitors of enzymes; anti-cancer drug discovery targeting protein-protein interactions;
cellulose/hemicellulose degrading enzymes for biofule production.
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Molecular and Cellular Signaling
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Protein Chemistry, Alzheimer's disease, prion, antimicrobial peptide
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Protein misfolding and neurodegenerative diseases.
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Protein misfolding in neurodegenerative diseases, Nanomedicine, Molecular probe development.
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Organic synthesis, chemical biology and drug discovery: We are interested in using organic chemistry as chemical tools to study and address in biology.
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Carbohydrate chemistry and biochemistry; carbohydrate-protein interactions studies.
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Natural medicine; Cancer pharmacology; Industrial enzyme biotechnology; Metabolomics
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Inflammation and cancer; induced pluripotent stem cells; vascular diseases; drug discovery and development.